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Invitrogen
GLP-1 Monoclonal Antibody (10), Biotin
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Product Details
ABS 033-10B-005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
10
Immunogen
Synthetic GLP-1(7-17).
Conjugate
Form
Liquid
Concentration
1.05 mg/mL
Amount
157.5 µg
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
ABS 033-10B-005 detects GLP1 from human samples. ABS 033-10B-005 is specific towards the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.
ABS 033-10B-005 has been successfully used in ELISA procedures.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
GCG is also known as GLP1, or Glucagon. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis.It is mapped to 2q36-2q37. GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus. Also, GLP1 is a potent insulin secretagogue.It plays a major role in the enteroinsular axis, accounting, for example, for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: glicentin-related polypeptide; GLP1/2; Glucagon like peptide 1; glucagon-like peptide 1; glucagon-like peptide 2; MGC138331; OXY; preproglucagon; Pro-glucagon
Gene Aliases: GCG; GLP-1; GLP1; GLP2; GRPP
UniProt ID: (Human) P01275
Entrez Gene ID: (Human) 2641
gluconeogenesis
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
feeding behavior
protein kinase A signaling
response to activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucose homeostasis
negative regulation of apoptotic process
positive regulation of gluconeogenesis
regulation of insulin secretion
positive regulation of ERK1 and ERK2 cascade
cellular response to glucagon stimulus
positive regulation of calcium ion import
negative regulation of execution phase of apoptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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